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RS 100329

CAS No. 1215654-26-4

RS 100329 ( RS-100329 )

Catalog No. M27696 CAS No. 1215654-26-4

RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 160 Get Quote
25MG 348 Get Quote
50MG 518 Get Quote
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Biological Information

  • Product Name
    RS 100329
  • Note
    Research use only, not for human use.
  • Brief Description
    RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.
  • Description
    RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.(In Vitro):In intact CHO-K1 cells expressing human cloned alpha1A-, alpha1B- and alpha1D-AR showed nanomolar affinity and significant alpha1A-AR subtype selectivity for RS 100329 hydrochloride (pKi 9.6: 126 and 50 fold selectivity) over the alpha1B- and alpha1D-AR subtypes respectively. Noradrenaline-induced contractions of human lower urinary tract (LUT) tissues or rabbit bladder neck were competitively antagonized by RS 100329 hydrochloride (pA2 9.2 and 9.2).
  • Synonyms
    RS-100329
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    EGFR;c-Met
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1215654-26-4
  • Formula Weight
    462.9
  • Molecular Formula
    C20H26ClF3N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C1=O)=CN=C(O)N1CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dokla EME, et al. 1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC. Eur J Med Chem. 2019 Aug 9;182:111607.
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