RS 100329

Research use only, not for human use.

RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.

RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.(In Vitro):In intact CHO-K1 cells expressing human cloned alpha1A-, alpha1B- and alpha1D-AR showed nanomolar affinity and significant alpha1A-AR subtype selectivity for RS 100329 hydrochloride (pKi 9.6: 126 and 50 fold selectivity) over the alpha1B- and alpha1D-AR subtypes respectively. Noradrenaline-induced contractions of human lower urinary tract (LUT) tissues or rabbit bladder neck were competitively antagonized by RS 100329 hydrochloride (pA2 9.2 and 9.2).

RS100329 hydrochloride (human lower urinary tract (LUT) tissues) contractions to Norepinephrine (HY-13715) is antagonized in a surmountable and concentration-dependent manner.

RS100329 hydrochloride (0.01-0.1 mg/kg; i.v.; Sprague Dawley rats) reduces baseline urethral pressure and inhibit reflex urethral contractions. Animal Model:Sprague Dawley rats (300-390 g) Dosage:0.01-0.1 mg/kg Administration:Intravenous injection Result:Caused a fall in baseline urethral pressure reaching a maximum of 23%.

RS-100329

Angiogenesis

Adrenergic Receptor

EGFR|c-Met

——

——

1215654-26-4

462.89

C20H26ClF3N4O3

>98% (HPLC)

In Vitro:?DMSO : 31.25 mg/mL (67.51 mM)

CC(C1=O)=CN=C(O)N1CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2.Cl

——

(-20℃)

With Ice Pack

≥ 2 years